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KMID : 0881720230380030079
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Journal of Food Hygiene and Safety
2023 Volume.38 No. 3 p.79 ~ p.88
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Selection and Validation of an Analytical Method for Trifludimoxazin in Agricultural Products with LC-MS/MS
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Gu Sun-Young
Lee Su-Jung
Lee So-Eun
Park Chae-Young
Lee Jung-Mi
Park In-Ju
Chung Yun-Mi
Jang Gui-Hyun
Moon Gui-Im
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Abstract
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Trifludimoxazin is a triazinone herbicide that inhibits the synthesis of protoporphyrinogen oxidase (PPO). The lack of PPO damages the cell membranes, leading to plant cell death. An official analytical method for the safety management of trifludimoxazin is necessary because it is a newly registered herbicide in Korea. Therefore, this study aimed to develop a residual analysis method to detect trifludimoxazin in five representative agricultural products. The EN method was established as the final extraction method by comparing the recovery test and matrix effect with those of the QuEChERS method. Various sorbent agents were used to establish the clean-up method, and no differences were observed among them. MgSO4 and PSA were selected as the final clean-up conditions. We used LC-MS/MS considering the selectivity and sensitivity of the target pesticide and analyzed the samples in the MRM mode. The recovery test results using the established analysis method and inter-laboratory validation showed a valid range of 73.5-100.7%, with a relative standard deviation and coefficient of variation less than 12.6% and 14.5%, respectively. Therefore, the presence of trifludimoxazin can be analyzed using a modified QuEChERS method, which is widely available in Korea to ensure the safety of residual insecticides.
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KEYWORD
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Herbicide, Trifludimoxazin, Analytical method, Agricultural product, LC-MS/MS
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